What is Testosterone? | Benefits | Side Effects Fitness&Beast Rating: 9.5 / 10
What is Testosterone? | Benefits | Side Effects
05/12/2018 10:37 AM
In my previous article I had divided Androgen Anabolic Steroids (AAS’s) into 5 main titles.
The first four of these titles are utilized by athletes actively. I had wrote about DHT and 17-alpha alkylated steroids in details.
This time I want to provide information related with one of these main titles: direct testosterone derivatives.
When we categorize the molecules in this title:
What is Testosterone?
Testosterone which belongs to hormone group called androgens, is a primary androgenic hormone. It is responsible from testicular and prostate growth.
Muscle tissue, bone density and strength are related to this hormone. It maintains general health.
The lack of testosterone effects not only muscular and bone structures but also mental status.
Even though it is an androgenic hormone it is also anabolic in a great exent. It is derived from cholesterol like all other steroid hormones and regulated by LH and FSH hormones.
LH and FSH hormones are secreted from pituitary gland by various stimuli. These two maintains testicular stimulation and secretion of testosterone.
The health of pituitary gland is as vital as testicular gland for production of testosterone.
The inventors of first synthetic testosterone for use of humans are Adolf Butenandt and Leopold Ruzicka. They won the Nobel prize in 1935 for their studies about testosterone.
First succesful testosterone injection was in a form of testosterone propionate. In a follow-up period other forms were put in the markets.
We have to keep in mind that all of the exogenous testosterone molecules are same in fact and the only difference comes from the esters which attach to the testosterone.
So what do esters change? They alter the release and activity duration.
Exogenous testosterone may be used as replacement therapy for increasing the testosterone levels to normal range in hormonal diseases or for augmentation of performance for athletes.
Whatever the purpose is, these benefits are maintained by testosterone:
Increase in the efficiency of recovery process
Muscles crush during the workout and structured during resting (recovery) phase. Testosterone speeds up the recovery time.
Strong anti-catabolic protection
Some hormones have negative effect on muscular tissue and increase the body fat levels. The best example for this process is cortisol hormone. Testosterone inhibits the cortisol hormone and decreases its level. By this way muscle tissue is saved and lipid levels are diminished.
Increase in the counts of red blood cells (RBC)
Testosterone enhances the durability and by this way the workout capacity is increased. The oxygen level entering the blood circulation is augmented by the increase in RBC’s so the efficiency of muscle tissues is maintained.
Increase in protein efficiency
Protein synthesis is boosted by the activity of testosterone. Muscle growth rate and level are enhanced by this way. Loss of muscle tissue is hindered by testosterone even if the carbonhydrate-free diet is maintained. Moreover the more protein accumulation is provided via the elevated nitrogene production.
Testosterone support which is also known as testosterone drug, testosterone pill or testosterone injection is mostly used in parenteral form.
Now let’s have a look at different testosterone molecules:
This testosterone form is accepted as original. It is attached with propionate ester. It is a short ester so the effect starts immediately.
The benefits are similar but half life which lasts 48 hours is different. For this reason it should be given frequently.
Most athletes use it every other day to maintain steady plasma level. Its water retention side effect is lower than others according to some articles.
Some users tell that the pain in the injection site is felt a little more than the other molecules.
The ester is long and effects slowly. It is a popular form. Half life is 15 days. Since it has a long half life, there are no needs for frequent injections while being used in hormone replacement therapies.
Nevertheless it is common for athletes to use it twice a week. The trade names like Testoviron Depot and Primoteston Depot are common.
It also carries long ester with a slow release. Anything told about enanthate is also valid for cypionate.
The only minor difference is that its half life is 24 hours longer than enanthate but this doesn’t change the injection frequency.
There are some urban legends that this form is stonger but it is not true since anabolic androgenic ratios are 100/100 for all pure testosterone molecules.
The difference of this molecule from others is that it doesn’t carry any ester. For this reason its absorption ratio is %100. This ratio is nearly %75 in others. It needs frequent injection because of not having ester.
Half life is short. At least once a day injection is needed. This molecule is water based contrast to others which are oil based. Being a water based molecule maintains its speed of action but also forms a painful injection.
Beacause of this painful injection, it is not preferred by some athletes.
It is formed of 4 different esters:
Testosterone Propionate:30 mg
Testosterone Phenylpropionate: 60 mg
Testosterone Isocaproate: 60 mg
Testosterone Decanoate: 100 mg
The purpose of production of this form by Organon Company is that it can be injected once a few weeks for hormone replacement therapy since frequent injections may lower the life quality for sick people.
But one or two injections per month is not sufficient for athletes.
Propionate or Phenypropionate are short and rapid esters. Isocaproate is intermediate, decanoate is long and slow ester.
For keeping the testosteron level high and steady, the injection twice/week is adequate.
Everything told about Sustanon-250 is also valid for Omnadren. The only difference is one of the four esters. Omnadren has caproate as the long ester instead of decanoate. The dose of caproate is 100 mg.
Trade name is Equipoise. It is the derivative of testosterone hormone. The only difference from testosterone is the double bond added to first and second carbon atoms.
The aim is to decrease the androgenic effects. By this way the estrogenic side effects also diminish. Undecyclonate ester is so large and long.
Maximum effect is reached four days after injection and slow release lasts 21 days. The bulking effect is less than testosterone molecules but because of less estrogenic effect it has more definite results.
The effects on protein synthesis, nitrogen retention, cortisol supression, the rise in red blood cells and IGF-1 output changes are same as testosterone.
Especially veterinarians utilize it for strengthening the horses. Its bulking effect is less than Deca-Duraboline, Anadrol and Dianabol. Anadrol and Dianabol has much water retention effect.
Boldenone provides power and stamina increase, accelerates recovery phase.
In cutting cycle, diet is performed so there is inevitable loss in lean muscle mass. Boldenon prevents lean muscle mass loss in this phase.
It is used in first phase of cutting cycle by most of the athletes since its potential estrogenic effect may cause trouble in latter phases.
Side effects are like other testosterone molecules but since it is a testosterone derivative and supresses endogenous testosterone production, concomitant exogenous testosteron is a must.
It was produced by Organon Company in the 1980’s. Its trade name is Andriol or Virigen Depots. It is an orally taken testosteron and different in this way.
Even though it is orally used, it is not hepatotoxic.
The reason for this is that it is not 17 alpha alkylated. It attaches to undecanoate ester and can be taken orally for it is oil based capsule.
Being a capsule not a tablet provides advantage in this way. Andriol Testocaps was put in the market in 2003.
The difference of it from Andriol is that it can be kept in room temperature and over the counter life span is 3 years.
However Andriol should be kept in the refrigerator and has a life span of 3 months. It is available as 40 mg capsule and absorbtion rate is %7.
Finally it is a testosterone molecule which has anabolic-androgenic ratio as 100-100. It is used for low testosterone treatment by sick people more than the athletes.
Athletes must consume too many capsules for increasing the muscle mass and this costs so expensive for them.
Using this capsule in cutting cycle is more logical. Fat income is minimum in the diet to decrease body fat ratio in cutting cycle.
Nevertheless less calorie income is needed along with the fats in cutting cycle so there is a risk of lean mass and strength decrease.
Andriol can prevent these declines.
Additionally it has a lipolytic effect so this is another advatage in cutting cycle. Beside it effects durability and recovery phase favorably.
The decrease in endogenous testesteron production while using other AAS’s can also be tolerated by concomitant using of Andriol.
Testosterone Side Effects
Testosterone excess may caose some troubles. Since the side effects of these molecules are common I want to emphasize them together:
Worsening of lipid profile
It has a basic mechanism. When exogenous testosterone is taken the body ceases to produce endogenous testosterone and since this endogenous testosterone is produced from testicular tissue, the unworked testis atrophies.
This is temporary side effect. When the exogenous testosterone is stopped being taken, the body begins to produce it again and testicular tissue returns to normal condition.
It is related with conversion to estrogen. Testo sterone is converted to estrogen by aromatase enzyme. This condition can be prevented by using of aromatase inhibitors.
This condition is also related with conversion to estrogen. Aromatase inhibitors such as Anastozole (Arimidex) or Femara (Letrozole) may prevent this but in some cases they are not useful. This side effect is not temporary so surgical approach may be needed.
Hypertension and Lipid Profile Worsening
Genetically succeptible individuals suffer more. Being on a diet and doing cardio exercises are important. Consuming omega 3 fatty acids may be useful in prevention.
Especially unqualified products cause it. Use of qualified molecules can prevent them.
Weekly dose of testosterone is 250 mg. Also some athletes consume it 500 mg/week. It is common to use it between 8-12 weeks.
It is exactly unhealthy to use it under the age of 18. Testo-sterone should be used under the care of physicians. Well regulated diet, strong body building and fitness programmes are vital.
Exogenous testosterone intake obligation is not needed since they are already direct testo-sterone molecules. The only exception is Boldenone Undecyclonate. Boldenone is a derivative of testosterone molecule whose androgenic effect is weak as I had mentioned under its title.
I will provide information about nandrolone hormone which is very strong in my next article…I have told that testosterone is a masculine hormone and if nandrolone were a natural masculine hormone, all the men would be stone age men 😊